Project Overview

The Singapore MIT Alliance for Research and Technology, Antimicrobial Resistance Interdisciplinary Research Group is seeking a Senior Laboratory Technologist / Laboratory Technologist for a project: “The pathobiology of tRNA modifications in cardiac development and diseased cell states”. This is a collaborative project with the NUS Yong Loo Lin School of Medicine to map the tRNA epitranscriptome and proteome in cardiac cell development and disease states. The successful candidate will utilize and acquire expertise in cardio-biology and multi-omics techniques, and contribute to impactful scientific research.

Key Responsibilities

This role will suit an individual passionate about cardio-biology and proteomics studies to understand molecular mechanisms of protein translation in heart development and disease. The candidate will be able to:

- Design and perform proteomics experiments (eg, TMT, DIA, DDA)

- Develop and optimize sample preparation workflows

- Perform operation, maintenance and data acquisition on high-resolution mass spectrometers

- Analyze data using advanced pipelines and support biological interpretation.

- Ensure compliance with lab safety, QC standards, and data integrity policies

- Maintains highly organized sample and data tracking and reporting workflow

The Duke-NUS Metabolomics Lab is a leading metabolomics core and research facility in Singapore, actively contributing to numerous projects aimed at uncovering disease mechanisms through advanced metabolomics profiling.

We are seeking a Research Fellow to play a key role in metabolomics-related research. The successful candidate will work both independently and collaboratively to analyse biological samples using mass spectrometry and multi-omics approaches. The research focuses on understanding the molecular mechanisms underlying diseases such as Amyotrophic Lateral Sclerosis (ALS), metabolic disorders, and the role of the gut microbiome in these conditions. Independently carry out the design and execution of experimental research required by the research component of the project.

• Independently design, plan, and execute experimental research aligned with project objectives.

• Write and review research papers, present research outcomes, conceptualise new ideas and develop plans for independent research which could have a considerable influence and impact on the relevant field attracting research funding.

• Provide support for external grant/protocol development, study design and management of research activities.

• Source financial support for research activities by investigating potential sources of funding, collaborate with Principal Investigator to write and revise grant/fellowship applications.

• Provide guidance and mentorship to junior researchers.

• Ensure optimal progress of experiments in the laboratory by conducting, supervising, and evaluating laboratory procedures and outcomes. Revise and analyse targets to obtain high-quality and reproducible results.

• Perform other related duties incidental to the work described therein.