Scientist at A*STAR IMCB
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23 January 2026 at 9:00:00 am
About the job
We are seeking a highly motivated Scientist/Research Fellow to join a multidisciplinary Pharma–Academia Joint Research Programme, focus on the discovery and development of next-generation therapeutic biologics and small molecules for ocular diseases. This position offers a unique opportunity to work at the interface of protein engineering, computational design, functional assays, and translational proteomics, within a highly collaborative environment bridging academic innovation and pharmaceutical development.
Key responsibilities:
Conduct affinity maturation and enzyme engineering using integrated dry-lab (in silico) and in vitro approaches
Design and execute selection strategies, including assay development, to support lead asset characterization, prioritization, and optimization
Perform and analyse protein–protein binding and enzyme kinetics data to guide iterative optimization cycles
Transitioning to lead proteomics-driven experiments to identify novel targets, and validate therapeutic mechanisms and assess drug targetability
Contribute to the advancement of lead biologics and small-molecule assets toward preclinical development.
Train junior researchers and students.
Work closely with the PI and project-coordinator, and team members in IMCB and the pharma partner.
Undertake related administrative and project coordination duties as required.
Requirements
Requirements:
PhD in Protein Engineering, Biochemistry, Chemical Biology, or a related life sciences discipline.
Demonstrated experience in binding/kinetic assays, affinity maturation and/or enzyme engineering, computational protein design, sequence analysis and variant prioritization
Understanding of protein–protein interactions, enzyme kinetics, and developability considerations for therapeutic candidates.
Experience working with biologics and/or small-molecule discovery pipelines is advantageous.
Strong ability to work collaboratively in interdisciplinary teams spanning biology, chemistry, computation, and translational science.
Excellent communication skills and ability to present scientific findings clearly.
1–2+ years of postdoctoral or equivalent experience in relevant areas is a plus.
Those who are interested may apply through A*STAR portal Career - Agency for Science, Technology and Research or send their CV to Prof Jayantha Gunaratne
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